Dimethylformamide → HCID 59346490, Verbindung

HRID 535371Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 535371
Cl.[Cl:2][C:3]1[C:4]([N:9]2[CH2:30][CH2:29][C:12]3[N:13]=[CH:14][N:15]=[C:16]([NH:17][C:18]4[CH:26]=[C:25]5[C:21]([C:22]([CH3:28])([CH3:27])[CH2:23][NH:24]5)=[CH:20][CH:19]=4)[C:11]=3[CH2:10]2)=[N:5][CH:6]=[CH:7][CH:8]=1.[CH3:31]N(C=O)C.C([O-])([O-])=O.[K+].[K+].CI>CCOC(C)=O>[Cl:2][C:3]1[C:4]([N:9]2[CH2:30][CH2:29][C:12]3[N:13]=[CH:14][N:15]=[C:16]([NH:17][C:18]4[CH:26]=[C:25]5[C:21]([C:22]([CH3:27])([CH3:28])[CH2:23][N:24]5[CH3:31])=[CH:20][CH:19]=4)[C:11]=3[CH2:10]2)=[N:5][CH:6]=[CH:7][CH:8]=1

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 68412802[6-(3-Chloro-pyridin-2-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-yl]-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-amine HCl salt

Produkt 1

HCID 59346490HCID 59346490, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a stirred mixture of [6-(3-chloro-pyridin-2-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-yl]-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-amine HCl salt (10 mg), DMF (5 mL), and K2CO3 (50 mg) was added MeI (50 μL). The reaction-mixture was stirred at rt for 5 h, and then diluted with EtOAc (50 mL). The organic phase was washed with brine, dried (Na2SO4) and concentrated. The residue was purified by column to give an off-white solid (7 mg).

Aufarbeitung

  1. washThe organic phase was washed with brine
  2. dry with materialdried (Na2SO4)
  3. concentrationconcentrated
  4. customThe residue was purified by column

Quellen und Nachweise

ORD-Eintrag
ord-3935c8653fbd4fcd8499d5bd458caaed
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08859545B2

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