3-Phenoxyphenylacetic acid → N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]-2-(3-phenoxyphenyl)acetamide

HRID 535553

Reaktionsgleichung

Reaktionsgleichung von HRID 535553
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[O:19]([C:26]1[CH:27]=[C:28]([CH2:32][C:33](O)=[O:34])[CH:29]=[CH:30][CH:31]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[N:12]1([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:18])[N:2]([NH:1][C:33](=[O:34])[CH2:32][C:28]3[CH:29]=[CH:30][CH:31]=[C:26]([O:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH:27]=3)[N:11]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Komponenten

3

Edukt 2

HCID 1417493-Phenoxyphenylacetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Produkt 1

HCID 70975958N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]-2-(3-phenoxyphenyl)acetamide

Versuchsvorschrift

The product of Example 1B and 2-(3-phenoxyphenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.30 (dd, J=7.9, 1.3 Hz, 1H), 8.03 (d, J=8.0 Hz, 1H), 7.97-8.01 (m, 1H), 7.89-7.93 (m, 1H), 7.36-7.43 (m, 3H), 7.14-7.18 (m, 2H), 7.00-7.08 (m, 3H), 6.91 (dd, J=8.2, 2.5 Hz, 1H), 3.80-3.85 (m, 4H), 3.67 (s, 2H) 3.06-3.12 (m, 4H); MS (ESI+) M/Z 457 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-85ad8259b57b44728b27272d1685c40e
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08859549B2

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