2-(2,4-Dimethoxyphenyl)acetic acid → 2-(2,4-dimethoxyphenyl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide

HRID 535591

Reaktionsgleichung

Reaktionsgleichung von HRID 535591
[NH2:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18].[CH3:19][O:20][C:21]1[CH:26]=[C:25]([O:27][CH3:28])[CH:24]=[CH:23][C:22]=1[CH2:29][C:30](O)=[O:31]>>[CH3:19][O:20][C:21]1[CH:26]=[C:25]([O:27][CH3:28])[CH:24]=[CH:23][C:22]=1[CH2:29][C:30]([NH:1][N:2]1[N:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:18])=[O:31]

Komponenten

3

Edukt 2

HCID 3505552-(2,4-Dimethoxyphenyl)acetic acidHCID 709761042-amino-4-morpholinophthalazin-1(2H)-one

Produkt 1

HCID 709760162-(2,4-dimethoxyphenyl)-N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]acetamide

Versuchsvorschrift

The product of Example 1B and 2-(2,4-dimethoxyphenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.31 (d, J=7.8 Hz, 1H), 8.03 (d, J=8.0 Hz, 1H), 7.97-8.00 (m, 1H), 7.89-7.92 (m, 1H), 7.22 (d, J=8.2 Hz, 1H), 6.56 (d, J=2.4 Hz, 1H), 6.51 (dd, J=8.2, 2.4 Hz, 1H), 3.82-3.84 (m, 4H), 3.80 (s, 3H), 3.76 (s, 3H), 3.53 (s, 2H), 3.06-3.14 (m, 4H); MS (ESI+) M/Z 425 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-30f670d105ac49339d24f7d1f71a0eca
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08859549B2

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