1-[4-(Bromomethyl)Phenyl]-1H-Pyrazole → 2-(4-(1H-pyrazol-1-yl)benzyl)-5-methyl-3-(methylthio)-7-neopentyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

HRID 535891Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 535891
CO[C:3]1[CH:28]=[CH:27][C:6]([CH2:7][N:8]2[C:16]([S:17][CH3:18])=[C:15]3[C:10]([N:11]([CH2:22][C:23]([CH3:26])([CH3:25])[CH3:24])[C:12](=[O:21])[N:13]([CH3:20])[C:14]3=[O:19])=[N:9]2)=[CH:5][CH:4]=1.BrCC1C=CC([N:37]2[CH:41]=[CH:40][CH:39]=[N:38]2)=CC=1>>[N:37]1([C:3]2[CH:4]=[CH:5][C:6]([CH2:7][N:8]3[C:16]([S:17][CH3:18])=[C:15]4[C:10]([N:11]([CH2:22][C:23]([CH3:24])([CH3:25])[CH3:26])[C:12](=[O:21])[N:13]([CH3:20])[C:14]4=[O:19])=[N:9]3)=[CH:27][CH:28]=2)[CH:41]=[CH:40][CH:39]=[N:38]1

Komponenten

3

Edukt 2

HCID 27764791-[4-(Bromomethyl)Phenyl]-1H-PyrazoleHCID 462239872-(4-methoxybenzyl)-5-methyl-3-(methylthio)-7-neopentyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Produkt 1

HCID 462239882-(4-(1H-pyrazol-1-yl)benzyl)-5-methyl-3-(methylthio)-7-neopentyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

Versuchsvorschrift

The synthetic procedure of this compound is analogous to EXAMPLE 5 wherein 2-(4-methoxybenzyl)-5-methyl-3-(methylthio)-7-neopentyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione is used instead of 2-(4-methoxybenzyl)-5-methyl-7-neopentyl-3-(phenylthio)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione, and 1-(4-(bromomethyl)phenyl)-1H-pyrazole is used instead of 1-(4-(bromomethyl)phenyl)-1H-1,2,4-triazole. MS (ESI) m/z 439.2 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-f984a3d89725436197a3ad4c48d959ad
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08859564B2

Notizen zur Reaktion

Wird geladen…