Dimethylamine → (s)-3-Bromo-n-(1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5h-imidazo[1,5-a][1,4]diazepine-1-carboxamide

HRID 535969

Reaktionsgleichung

Reaktionsgleichung von HRID 535969
[Br:1][C:2]1[N:6]2[CH2:7][CH2:8][CH2:9][N:10]([CH3:12])[CH2:11][C:5]2=[C:4]([C:13](N[C@@H](CC(C)C)C(NC)=O)=[O:14])[N:3]=1.[NH2:25][C@H:26]([C:31]([OH:33])=O)[C:27]([CH3:30])([CH3:29])[CH3:28].[CH3:34][NH:35][CH3:36]>C1COCC1>[Br:1][C:2]1[N:6]2[CH2:7][CH2:8][CH2:9][N:10]([CH3:12])[CH2:11][C:5]2=[C:4]([C:13]([NH:25][C@@H:26]([C:27]([CH3:30])([CH3:29])[CH3:28])[C:31]([N:35]([CH3:36])[CH3:34])=[O:33])=[O:14])[N:3]=1

Komponenten

5

Edukt 3

HCID 674DimethylamineHCID 164608L-tert-LeucineHCID 57635259(S)-3-bromo-8-methyl-N-(4-methyl-1-(methylamino)-1-oxopentan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide2×

Produkt 1

HCID 57635558(s)-3-Bromo-n-(1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5h-imidazo[1,5-a][1,4]diazepine-1-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

This intermediate was prepared following the synthesis of ((S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-bromo-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide (Intermediate 55B) by replacing Z-Leu-OH with tert-Leu-OH, and replacing methylamine hydrochloride with dimethylamine solution in THF. LCMS (+ESI) m/z 417.1 [M+H]+.

Aufarbeitung

  1. customThis intermediate was prepared

Quellen und Nachweise

ORD-Eintrag
ord-e0de0e797d0d440eb3ff29d772cbc0cb
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08859538B2

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