Thionyl Chloride → 4-(Chloromethyl)-3-fluoropyridine hydrochloride
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8]O.S(Cl)([Cl:12])=O>C(#N)C>[ClH:12].[Cl:12][CH2:8][C:7]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[F:1]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
6.710 g (52.785 mmol) of (3-fluoropyridin-4-yl)methanol was put in 29 ml acetonitrile and heated to 50° C. Then a solution of 7.701 ml thionyl chloride in 14.5 ml acetonitrile was added dropwise and the reaction mixture was stirred for 4 h at 50° C. Then the reaction mixture was concentrated by evaporation and was co-distilled three times with dichloromethane. After drying under high vacuum, 10.27 g of the title compound was obtained, which was used in the next step without further purification.
Aufarbeitung
- concentrationThen the reaction mixture was concentrated by evaporation
- customAfter drying under high vacuum
Quellen und Nachweise
- ORD-Eintrag
- ord-53cd80e5e96045c68d55a431d243c5a9
- Quelldatensatz
- uspto-grants-2014_10
- Patentnummer
- US08859569B2
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