Potassium Carbonate → Ethyl 5-amino-1-isopropyl-1H-pyrazole-4-carboxylate

HRID 537093

Reaktionsgleichung

Reaktionsgleichung von HRID 537093
[C:1]([C:3](=[CH:9]OCC)[C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2].Cl.[CH:14]([NH:17][NH2:18])([CH3:16])[CH3:15].C(=O)([O-])[O-].[K+].[K+]>C(O)C.CO>[NH2:2][C:1]1[N:17]([CH:14]([CH3:16])[CH3:15])[N:18]=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 789432-Propenoic acid, 2-cyano-3-ethoxy-, ethyl esterHCID 855731-Isopropylhydrazine hydrochloride

Produkt 1

HCID 22762155Ethyl 5-amino-1-isopropyl-1H-pyrazole-4-carboxylateAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 18681192Ethanol, mixt. with methanolLösungsmittel

Versuchsvorschrift

A mixture of ethyl 2-cyano-3-ethoxyacrylate (84.4 g, 0.50 mol), isopropyl hydrazine hydrochloride (55.2 g, 0.50 mol) and potassium carbonate (68.8 g, 0.50 mol) in 90% ethanol/methanol (1.5 L) was heated under reflux for 16 hours. The solvent was then removed in vacuo and water and ethyl acetate were added. The mixture was separated and the organic layer was dried over magnesium sulfate, filtered and the solvent was removed in vacuo to yield ethyl 5-amino-1-isopropyl-1H-pyrazole-4-carboxylate (92.4 g, 94%). +ESI (M+H) 198.1; 1H NMR (400 MHz, CDCl3, δ): 7.63 (s, 1H), 4.97 (br. s., 2H), 4.28 (q, 2H), 4.18 (m, 1H), 1.45 (d, 6H), 1.31 (t, 3H).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 16 hours
  3. customThe solvent was then removed in vacuo and water and ethyl acetate
  4. additionwere added
  5. customThe mixture was separated
  6. dry with materialthe organic layer was dried over magnesium sulfate
  7. filtrationfiltered
  8. customthe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-899d5432338e466ca41209097754de76
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08859773B2

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