methyl (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate → HCID 20782721, Verbindung
Reaktionsgleichung
CC1(C)[C@H]2[C@@H]1CN[C@@H]2C#N.[CH3:11][O:12][C:13]([C@H:15]1[NH:20][CH2:19][C@H:18]2[C@@H:16]1[C:17]2([CH3:22])[CH3:21])=[O:14]>>[CH3:11][O:12][C:13]([CH:15]1[NH:20][CH2:19][CH:18]2[CH:16]1[C:17]2([CH3:22])[CH3:21])=[O:14]Komponenten
3
Versuchsvorschrift
The (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carbonitrile prepared according to Example 16 or 17 is converted to the corresponding substantially enantiomerically pure (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid methyl ester by the procedure described in PCT International Application Publication WO 2007/075790.
Quellen und Nachweise
- ORD-Eintrag
- ord-768546c6d2434d21a6bc02483ce6f7d9
- Quelldatensatz
- uspto-grants-2014_10
- Patentnummer
- US08859784B2
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