N-[4-Chloro-2-nitro-5-(trifluoromethyl)phenyl]acetamide → 4-Chloro-2-nitro-5-(trifluoromethyl)aniline

HRID 53782

Reaktionsgleichung

Reaktionsgleichung von HRID 53782
C([NH:4][C:5]1[CH:6]=[C:7]([C:15]([F:18])([F:17])[F:16])[C:8]([Cl:14])=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])(=O)C>Cl>[NH2:4][C:5]1[CH:6]=[C:7]([C:15]([F:18])([F:16])[F:17])[C:8]([Cl:14])=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12]

Komponenten

3

Edukt 1

HCID 22318004N-[4-Chloro-2-nitro-5-(trifluoromethyl)phenyl]acetamide

Produkt 1

HCID 27376454-Chloro-2-nitro-5-(trifluoromethyl)anilineAusbeute 78 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

A mixture of 3-acetamido-6-chloro-4-nitrobenzotrifluoride (780 mg, 2.76 mmol) in concentrated HCl (3 mL) was refluxed overnight and it was extracted by ethyl acetate (2×3 mL). The extract was dried over Mg2SO4 and evaporated to give 517 mg (78% ) of 3-amino-6-chloro-4-nitrobenzotrifluoride. 1H NMR (CDCl3): δ 6.205 (S, 2H); 7.206 (s, 1H); 8.263 (s, 1H).

Aufarbeitung

  1. temperaturewas refluxed overnight
  2. extractionit was extracted by ethyl acetate (2×3 mL)
  3. dry with materialThe extract was dried over Mg2SO4
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-971afb0efd3a4d0d94a318d0837f4da0
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05620979

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