3-Chloro-2-butanone → 2-(4-Methoxy-phenyl)-4,5-dimethyl-oxazole

HRID 538569Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 538569
Cl[CH:2]([CH3:6])[C:3](=O)[CH3:4].[CH3:7][O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([NH2:15])=[O:14])=[CH:11][CH:10]=1>>[CH3:7][O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]2[O:14][C:2]([CH3:6])=[C:3]([CH3:4])[N:15]=2)=[CH:11][CH:10]=1

Komponenten

3

Edukt 2

HCID 200263-Chloro-2-butanoneHCID 769594-Methoxybenzamide

Produkt 1

HCID 189829612-(4-Methoxy-phenyl)-4,5-dimethyl-oxazoleAusbeute 83,6 %

Reaktionsbedingungen

Temperatur
115 °C

Versuchsvorschrift

A mixture of 3-Chloro-2-butanone (2.1 g, 10.0 mmol) and 4-methoxybenzamide (0.30 g, 1.0 mmol) was heated at 115° C. for 15 h under nitrogen atmosphere. After the completion of the reaction mixture (TLC monitoring), the reaction mixture was evaporated to dryness under reduced pressure and the residue was purified over silica gel (230-400 M, 20% EtOAc-Hexane) to get the desired product (0.17 g, 42%) as a white solid. The corresponding chloro derivative was also prepared by the same general method.

Aufarbeitung

  1. customAfter the completion of the reaction mixture (TLC monitoring), the reaction mixture was evaporated to dryness under reduced pressure
  2. customthe residue was purified over silica gel (230-400 M, 20% EtOAc-Hexane)

Quellen und Nachweise

ORD-Eintrag
ord-2fc9b50ee16d406287a89371fd62a344
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08865736B2

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