Sodium Hydroxide → 4-(2-ethyl-1-(1H-imidazol-1-yl)butyl)aniline

HRID 538885Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 538885
[CH2:1]([CH:3]([CH2:20][CH3:21])[CH:4]([C:10]1[CH:15]=[CH:14][C:13]([NH:16]C(=O)C)=[CH:12][CH:11]=1)[N:5]1[CH:9]=[CH:8][N:7]=[CH:6]1)[CH3:2].[OH-].[Na+]>Cl>[CH2:20]([CH:3]([CH2:1][CH3:2])[CH:4]([C:10]1[CH:11]=[CH:12][C:13]([NH2:16])=[CH:14][CH:15]=1)[N:5]1[CH:9]=[CH:8][N:7]=[CH:6]1)[CH3:21]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 86681896N-(4-(2-ethyl-1-(1H-imidazol-1-yl)butyl)phenyl)acetamide

Produkt 1

HCID 866818974-(2-ethyl-1-(1H-imidazol-1-yl)butyl)aniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

A solution of N-(4-(2-ethyl-1-(1H-imidazol-1-yl)butyl)phenyl)acetamide (350 mg, 1.23 mmol) in 3N HCl (3.28 mL) was stirred overnight at 60° C. After cooling to room temperature, the solution was poured onto ice and basified with 6N NaOH (pH=12-14). The aqueous phase was extracted three times with DCM and the organic extracts were combined and dried over MgSO4, filtered and then concentrated to afford to 4-(2-ethyl-1-(1H-imidazol-1-yl)butyl)aniline, MS (ES+): m/z 244.31 (MH+).

Aufarbeitung

  1. additionthe solution was poured onto ice
  2. extractionThe aqueous phase was extracted three times with DCM
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-2cc84e9059b24a87819c442c8f8fad7a
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08865752B2

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