Hydrochloric Acid → (R)-2-amino-2-(2,4-difluorophenyl)ethanol hydrochloride
Reaktionsgleichung
[Si]([O:8][CH2:9][C@H:10]([NH:19][S@](C(C)(C)C)=O)[C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=1[F:18])(C(C)(C)C)(C)C.[ClH:26].O1CCOCC1>CO>[ClH:26].[NH2:19][C@H:10]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=1[F:18])[CH2:9][OH:8]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 0 °C
Versuchsvorschrift
To a mixture of (S)—N—((R)-2-(tert-butyldimethylsilyloxy)-1-(2,4-difluorophenyl)ethyl)-2-methylpropane-2-sulfinamide (1.08 g, 2.76 mmol) in MeOH (8 mL) was added 4N HCl in dioxane (6.9 mL, 28 mmol) at 0° C. under N2. The reaction mixture was stirred at 0° C. for 4 hours. The solvents were evaporated in vacuo to give (R)-2-amino-2-(2,4-difluorophenyl)ethanol hydrochloride (0.58 g, 100%) as a white solid, which was used in the next step without further purification.
Aufarbeitung
- customThe solvents were evaporated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-dff5a1d4fce34cfa93aec2aff36da462
- Quelldatensatz
- uspto-grants-2014_10
- Patentnummer
- US08865726B2
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