2-(Isopropyl)-5-methylcyclohexylamine → HCID 86629952, Verbindung
Reaktionsgleichung
[CH3:1][CH:2]1[CH2:7][CH:6]([NH2:8])[CH:5]([CH:9]([CH3:11])[CH3:10])[CH2:4][CH2:3]1.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH2:22][C:23](Cl)=[O:24])[CH:17]=[CH:18][C:19]=1[O:20][CH3:21]>>[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH2:22][C:23]([NH:8][C@H:6]2[CH2:7][C@H:2]([CH3:1])[CH2:3][CH2:4][C@H:5]2[CH:9]([CH3:11])[CH3:10])=[O:24])[CH:17]=[CH:18][C:19]=1[O:20][CH3:21].[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH2:22][C:23]([NH:8][C@@H:6]2[CH2:7][C@@H:2]([CH3:1])[CH2:3][CH2:4][C@@H:5]2[CH:9]([CH3:11])[CH3:10])=[O:24])[CH:17]=[CH:18][C:19]=1[O:20][CH3:21]Komponenten
3
Versuchsvorschrift
The aforementioned product is obtained as a colorless solid containing in total 94.2% of the desired neomenthylamine derivatives from racemic neomenthylamine, as in the GP, by reaction with (3,4-dimethoxyphenyl)acetyl chloride. Furthermore, two further isomeric menthylamine derivatives are present at 2.7% and 2.5%, corresponding to a purity over all stereoisomers of 99.4%.
Aufarbeitung
- customThe aforementioned product is obtained as a colorless solid