Triethylamine → N-[(3-Aminooxetan-3-yl)methyl]-2-chloroquinazolin-4-amine

HRID 540202Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 540202
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:13][CH2:14][C:15]1([NH2:19])[CH2:18][O:17][CH2:16]1.C(N(CC)CC)C>CO>[NH2:19][C:15]1([CH2:14][NH:13][C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=[C:2]([Cl:1])[N:11]=2)[CH2:18][O:17][CH2:16]1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 2528862,4-DichloroquinazolineHCID 217130163-(Aminomethyl)oxetan-3-amine

Produkt 1

HCID 86691405N-[(3-Aminooxetan-3-yl)methyl]-2-chloroquinazolin-4-amineAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2,4-dichloroquinazoline (1.0 g, 5.024 mmol) in methanol (15 mL) was added 3-(aminomethyl)oxetan-3-amine (855 mg, 60%, 5.024 mmol) and triethylamine (101 mg, 1.005 mmol). After being stirred at room temperature overnight, the mixture was concentrated in vacuo. The residue was purified by flash column chromatography to afford 1.2 g of the desired product as a white solid (yield was 92%).

Aufarbeitung

  1. concentrationthe mixture was concentrated in vacuo
  2. customThe residue was purified by flash column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-ed5f1cc09e1e4dbab5a9729bda253ceb
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08871756B2

Notizen zur Reaktion

Wird geladen…