2,3,4,5-Tetrahydrobenzo[f][1,4]thiazepine → HCID 71255080, Verbindung

HRID 540290Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 540290
[CH2:1]([O:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([Br:19])[CH:17]=2)[N:12]=[C:11](Cl)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:21]1[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=2[CH2:25][NH:24][CH2:23][CH2:22]1>>[CH2:1]([O:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([Br:19])[CH:17]=2)[N:12]=[C:11]([N:24]2[CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[S:21][CH2:22][CH2:23]2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 122691062,3,4,5-Tetrahydrobenzo[f][1,4]thiazepineHCID 86691432HCID 86691432, Verbindung

Produkt 1

HCID 71255080HCID 71255080, VerbindungAusbeute 62,7 %

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of 4-(benzyloxy)-6-bromo-2-chloroquinazoline (700 mg, 2.0 mmol) and 2,3,4,5-tetrahydro-1,4-benzothiazepine (990 mg, 6.0 mmol) was heated at 80° C. for 10 minutes. The resulting reaction mixture was cooled to room temperature and purified by silica gel column chromatography (eluting with dichloromethane) to afford 600 mg of the desired product as a white solid (yield was 62.7%).

Aufarbeitung

  1. customThe resulting reaction mixture
  2. temperaturewas cooled to room temperature
  3. custompurified by silica gel column chromatography (eluting with dichloromethane)

Quellen und Nachweise

ORD-Eintrag
ord-f6c540c3012b473aa009554a7e57de02
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08871756B2

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