Triethylamine → HCID 178423399, Verbindung

Reaktionsgleichung

Cl[C:2]1[NH:11][C:10](=[O:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH2:13]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[C:17](=[O:24])[CH2:16][CH2:15][NH:14]1.[CH2:25](N(CC)CC)C>C1(C)C=CC=CC=1>[OH:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:25])[CH:8]=2)[N:3]=[C:2]([N:14]2[CH2:15][CH2:16][C:17](=[O:24])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[CH2:13]2)[N:11]=1

Komponenten

Versuchsvorschrift

To a stirred solution of 2-chloro-4(3H)-quinazolinone (580 mg, 3.0 mmol) and 1,2,3,4-tetrahydro-5H-2-benzazepin-5-one (591 mg, 3.0 mmol) in toluene (20 mL) was added triethylamine (626 μL, 4.5 mmol). After being refluxed overnight, the resulting reaction mixture was cooled and the formed solid was collected by filtration, washed with ethanol (10 mL) and ethyl acetate (10 mL), and dried in vacuo to afford 775 mg of the desired product as a white solid (yield was 81%).