Trifluoroacetic acid → 3-Cyclohexylazetidin-3-ol trifluoroacetate

HRID 540373Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 540373
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH:8]1([C:14]2([OH:25])[CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]2)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH:8]1([C:14]2([OH:25])[CH2:17][NH:16][CH2:15]2)[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 659194093-Cyclohexyl-3-hydroxy-1-(tert-butoxycarbonyl)azetidine

Produkt 1

HCID 669884123-Cyclohexylazetidin-3-ol trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1 ml of trifluoroacetic acid is added to a solution containing 120 mg (0.47 mmol) of 3-cyclohexyl-3-hydroxy-1-(tert-butoxycarbonyl)azetidine dissolved in 3 ml of dichloromethane. The reaction medium is stirred at ambient temperature for 1 hour and then concentrated to dryness and used without further purification.

Aufarbeitung

  1. concentrationconcentrated to dryness
  2. customused without further purification

Quellen und Nachweise

ORD-Eintrag
ord-e8444eb0ec484519bd17a0bb83406124
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08871187B2

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