Trifluoroacetic acid → HCID 66988236, Verbindung

HRID 540407Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 540407
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]([O:12][C:13]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[F:30])[CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14]1)[CH2:9][CH2:10][CH3:11]>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]([O:12][C:13]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[F:30])[CH2:14][NH:15][CH2:16]1)[CH2:9][CH2:10][CH3:11]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 669889981,1-Dimethylethyl 3-butoxy-3-(2-fluorophenyl)-1-azetidinecarboxylate

Produkt 1

HCID 66988236HCID 66988236, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1 ml of trifluoroacetic acid is added to a solution containing 104 mg (0.3 mmol) of 3-butoxy-3-(2-fluorophenyl)-1-(tert-butoxycarbonyl)azetidine in 3 ml of dichloromethane at 0° C. After stirring for 30 minutes, the reaction medium is evaporated off under a stream of nitrogen. 126 mg of 3-butoxy-3-(2-fluorophenyl)azetidine trifluoroacetate are obtained in the form of a pale yellow oil with a yield of 100%.

Aufarbeitung

  1. customthe reaction medium is evaporated off under a stream of nitrogen

Quellen und Nachweise

ORD-Eintrag
ord-ed8c916a879141e3a83d2fe1c92a796b
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08871187B2

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