10-Mercaptomethyl-3-t-butoxycarbonylmethyl-2-oxo-1-azacyclodecane → 10-Mercaptomethyl-2-oxo-1-azacyclodecane-3-acetic acid

HRID 5408

Reaktionsgleichung

Reaktionsgleichung von HRID 5408
[SH:1][CH2:2][CH:3]1[NH:12][C:11](=[O:13])[CH:10]([CH2:14][C:15]([O:17]C(C)(C)C)=[O:16])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1>C(Cl)Cl>[SH:1][CH2:2][CH:3]1[NH:12][C:11](=[O:13])[CH:10]([CH2:14][C:15]([OH:17])=[O:16])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1

Komponenten

3

Edukt 1

HCID 1993080710-Mercaptomethyl-3-t-butoxycarbonylmethyl-2-oxo-1-azacyclodecane

Produkt 1

HCID 1993085410-Mercaptomethyl-2-oxo-1-azacyclodecane-3-acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

10-Mercaptomethyl-3-t-butoxycarbonylmethyl-2-oxo-1-azacyclodecane (0.21 g, 0.69 mmol) is dissolved in methylene chloride (15 mL). Gaseous hydrogen chloride is bubbled through the solvent for 15 minutes, and then the reaction is sealed and stirred overnight. The solvent is evaporated the next day to give 10-mercaptomethyl-2-oxo-1-azacyclodecane-3-acetic acid, MS: M+1=260.

Aufarbeitung

  1. customGaseous hydrogen chloride is bubbled through the solvent for 15 minutes
  2. customthe reaction is sealed
  3. customThe solvent is evaporated the next day

Quellen und Nachweise

ORD-Eintrag
ord-3ff5ad5cf75d47f1b22289091515d997
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05244889

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