1-Aminotetralin, (S)- → (s)-1,2,3,4-Tetrahydronaphthalen-1-aminium (1s,3ar,6as)-2-(t-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

The ethyl acetate solution of racemic N-t-butyloxycarbonyl-3-azabicyclo[3.3.0]octane-2-carboxylic acid from Example 2, Method 2, was added to a solution of (S)-1,2,3,4-tetrahydro-1-naphthylamine (56.7 g, 0.385 mol) in ethyl acetate (300 mL). The mixture was stirred for 3-4 hours at 22-25° C., then filtered, and the solids washed with ethyl acetate (200 mL). The product was dried at 20-30° C. under vacuum for 4 hours to give the title compound.

Herkunft & Nachweise