Sodium Hydroxide → 2'-Methyl-biphenyl-2,4'-dicarboxylic acid

Temperatur

100 °C

A mixture of 2-ethyl 4′-methyl 2′-methyl-biphenyl-2,4′-dicarboxylate (2.404 g), ethanol (12 ml) and 4N aqueous sodium hydroxide solution (6 ml) was stirred at 100° C. overnight. After completion of the reaction, the reaction mixture was concentrated under reduced pressure, and water (50 ml) was added to the obtained residue. This mixture was adjusted to pH 1 with 6N hydrochloric acid (5 ml), ethanol (10 ml) was added, and the mixture was stirred at room temperature for 10 min. This suspension was filtered, the obtained solid was washed with 20 v/v % ethanol-water (10 ml), air-dried, and dried under reduced pressure at 80° C. to give the title compound (1.957 g, 95%).

1. customAfter completion of the reaction
2. concentrationthe reaction mixture was concentrated under reduced pressure, and water (50 ml)
3. additionwas added to the obtained residue
4. additionwas added
5. stirringthe mixture was stirred at room temperature for 10 min
6. filtrationThis suspension was filtered
7. washthe obtained solid was washed with 20 v/v % ethanol-water (10 ml)
8. customair-dried
9. customdried under reduced pressure at 80° C.

ORD-Eintrag

ord-8a453cca6f3343f991c55d8ca946965a

Quelldatensatz

uspto-grants-2014_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08871934B2