Einecs 211-027-4 → 3-Hydroxy-indeno[1,2-b]pyridin-5-one

HRID 541151Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 541151
C[O:2][C:3]1[CH:4]=[C:5]2[C:15](=[O:16])[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:6]2=[N:7][CH:8]=1.[Cl-].[NH+]1C=CC=CC=1>N1C=CC=CC=1>[OH:2][C:3]1[CH:4]=[C:5]2[C:15](=[O:16])[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:6]2=[N:7][CH:8]=1

Komponenten

4

Edukt 2

HCID 69401Einecs 211-027-4HCID 594930653-Methoxy-indeno[1,2-b]pyridin-5-one

Produkt 1

HCID 594925083-Hydroxy-indeno[1,2-b]pyridin-5-oneAusbeute 10,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
180 °C

Versuchsvorschrift

Under an argon atmosphere, 3-methoxy-indeno[1,2-b]pyridin-5-one (0.545 g) and pyridinium chloride (5.89 g) were mixed with pyridine (1.0 ml). The reaction mixture was stirred with heating at 180° C. for 30 min while evaporating pyridine, and further stirred with heating at 200° C. for 4 hr. The mixture was cooled to room temperature, water was added and the mixture was stirred for 30 min. This slurry was filtered, and the obtained solid was dried under reduced pressure to give the title compound (0.054 g). The obtained solid was used for the next reaction without further purification.

Aufarbeitung

  1. customwhile evaporating pyridine
  2. stirringfurther stirred
  3. temperaturewith heating at 200° C. for 4 hr
  4. temperatureThe mixture was cooled to room temperature
  5. additionwater was added
  6. stirringthe mixture was stirred for 30 min
  7. filtrationThis slurry was filtered
  8. customthe obtained solid was dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f428e289ddec4cc284fdab8226f447db
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08871934B2

Notizen zur Reaktion

Wird geladen…