5-Nitro-2-(1-pyrrolidinyl)pyridine → 6-(Pyrrolidin-1-yl)pyridin-3-amine

HRID 541221

Reaktionsgleichung

Reaktionsgleichung von HRID 541221
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[N:8][CH:9]=1)([O-])=O>C(O)C>[N:10]1([C:7]2[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)[CH2:14][CH2:13][CH2:12][CH2:11]1

Komponenten

3

Edukt 1

HCID 3168235-Nitro-2-(1-pyrrolidinyl)pyridine2×

Produkt 1

HCID 38991726-(Pyrrolidin-1-yl)pyridin-3-amineAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Around-bottom flask, containing a solution of 5-nitro-2-(pyrrolidin-1-yl)pyridine (compound 40.1, 1.93 g, 10.00 mmol, 1.00 equiv) in ethanol (30 mL) was purged with nitrogen. Palladium on carbon (0.4 g, 10%, 60% water) was added. After further purging the system with nitrogen, the atmosphere was changed to hydrogen and the resulting mixture was stirred overnight at room temperature. After purging the system with nitrogen, the solids were filtered off and the filtrate was concentrated under reduced pressure and dried to yield 1.6 g (98%) of the title compound as a brown solid.

Aufarbeitung

  1. customwas purged with nitrogen
  2. additionPalladium on carbon (0.4 g, 10%, 60% water) was added
  3. customAfter further purging the system with nitrogen
  4. customAfter purging the system with nitrogen
  5. filtrationthe solids were filtered off
  6. concentrationthe filtrate was concentrated under reduced pressure
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-08683304d07f4398a320d3dacf0cb6e4
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08871790B2

Verknüpfte Notizen

Wird geladen…