3,5-Dimethylisoxazole-4-carbonyl Chloride → N-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-1-[(3,5-dimethylisoxazol-4-yl)carbonyl]piperidine-4-carboxamide Trifluoroacetate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	3,5-Dimethylisoxazole-4-carbonyl Chloride	HCID 2736265	—
Edukt	N-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]piperidine-4-carboxamide bis(trifluoroacetate)	HCID 86636132	—
Produkt	N-[6-Chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20), 3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-1-[(3,5-dimethylisoxazol-4-yl)carbonyl]piperidine-4-carboxamide Trifluoroacetate	HCID 86636135	36%

Reaktionsschritte

The desired compound was prepared according to the procedure of Example A20, using N-[6-chloro-2,4,8,22-tetraazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]piperidine-4-carboxamide bis(trifluoroacetate) and 3,5-dimethylisoxazole-4-carbonyl chloride as starting materials in 36% yield. LCMS for C30H31ClN7O3 (M+H)+: m/z=572.2.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08871753B2
Quelldatensatz	uspto-grants-2014_10
ORD ID	ord-e1836ed1be7b47febd7f95f5673a42fa
Quellennotiz	uspto-grants-2014_10