2-Chlorothiazole → N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-[1-(1,3-thiazol-2-yl)piperidin-4-yl]acetamide tris(trifluoroacetate)

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-Chlorothiazole	HCID 76429	—
Edukt	N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate)	HCID 86636131	—
Produkt	N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-[1-(1,3-thiazol-2-yl)piperidin-4-yl]acetamide tris(trifluoroacetate)	HCID 86636206	12%

Reaktionsschritte

The desired compound was prepared according to the procedure of Example A157, using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate) and 2-chloro-1,3-thiazole as starting materials in 12% yield. LCMS for C27H28ClN8OS (M+H)+: m/z=547.2.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08871753B2
Quelldatensatz	uspto-grants-2014_10
ORD ID	ord-3d93ef87ae4d4660949375f095894269
Quellennotiz	uspto-grants-2014_10