5-methyl-1H-pyrazole-3-carboxylic acid → N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-{1-[(5-methyl-1H-pyrazol-3-yl)carbonyl]piperidin-4-yl}acetamide bis(trifluoroacetate)

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	5-methyl-1H-pyrazole-3-carboxylic acid	HCID 9822	—
Edukt	N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide bis(trifluoroacetate)	HCID 86636208	—
Produkt	N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-{1-[(5-methyl-1H-pyrazol-3-yl)carbonyl]piperidin-4-yl}acetamide bis(trifluoroacetate)	HCID 86636211	29%

Reaktionsschritte

The desired compound was prepared according to the procedure of Example A27, using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide bis(trifluoroacetate) and 5-methyl-1H-pyrazole-3-carboxylic acid as starting materials in 29% yield. LCMS for C29H31ClN9O2 (M+H)+: m/z=572.2.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08871753B2
Quelldatensatz	uspto-grants-2014_10
ORD ID	ord-65b2c2ec9afc40aca9881a63e2fa27bd
Quellennotiz	uspto-grants-2014_10