5-Methyl-1,2-oxazole-4-sulfonyl chloride → N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-{1-[(5-methylisoxazol-4-yl)sulfonyl]piperidin-4-yl}acetamide bis(trifluoroacetate)

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	5-Methyl-1,2-oxazole-4-sulfonyl chloride	HCID 2776141	—
Edukt	N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate)	HCID 86636131	—
Produkt	N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-{1-[(5-methylisoxazol-4-yl)sulfonyl]piperidin-4-yl}acetamide bis(trifluoroacetate)	HCID 86636230	12%

Reaktionsschritte

The desired compound was prepared according to the procedure of Example A42 using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate) and 5-methylisoxazole-4-sulfonyl chloride as starting materials in 12% yield. LCMS for C28H30ClN8O4S (M+H)+: m/z=609.2.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08871753B2
Quelldatensatz	uspto-grants-2014_10
ORD ID	ord-0dd9baf7a6c444c088c3f158d2ca4dfc
Quellennotiz	uspto-grants-2014_10