HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Fluorophenyl isocyanate → (3S)-3-(2-{[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]amino}-2-oxoethyl)-N-(3-fluorophenyl)pyrrolidine-1-carboxamide bis(trifluoroacetate)
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Fluorophenyl isocyanate | HCID 123064 | — |
| Edukt | N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-[(3S)-pyrrolidin-3-yl]acetamide tris(trifluoroacetate) | HCID 86636313 | — |
| Produkt | (3S)-3-(2-{[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]amino}-2-oxoethyl)-N-(3-fluorophenyl)pyrrolidine-1-carboxamide bis(trifluoroacetate) | HCID 86636319 | 80% |
Reaktionsschritte
The desired compound was prepared according to the procedure of Example D41 using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-[(3S)-pyrrolidin-3-yl]acetamide tris(trifluoroacetate) and 1-fluoro-3-isocyanatobenzene as the starting materials in 80% yield. LCMS for C30H29ClFN8O2 (M+H)+: m/z=587.0.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08871753B2 |
| Quelldatensatz | uspto-grants-2014_10 |
| ORD ID | ord-aaa8822a5c78474eae4a9812bd6f18a0 |
| Quellennotiz | uspto-grants-2014_10 |