1-Fluoro-2-iodo-4-nitrobenzene → Benzyl 4-[(2-iodo-4-nitrophenyl)amino]piperidine-1-carboxylate

HRID 541998

Reaktionsgleichung

Reaktionsgleichung von HRID 541998
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[I:11].[NH2:12][CH:13]1[CH2:18][CH2:17][N:16]([C:19]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[O:20])[CH2:15][CH2:14]1>>[I:11][C:3]1[CH:4]=[C:5]([N+:8]([O-:10])=[O:9])[CH:6]=[CH:7][C:2]=1[NH:12][CH:13]1[CH2:14][CH2:15][N:16]([C:19]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[O:20])[CH2:17][CH2:18]1

Komponenten

3

Edukt 2

HCID 105397331-Fluoro-2-iodo-4-nitrobenzeneHCID 178466404-Amino-1-N-Cbz-piperidine

Produkt 1

HCID 57962346Benzyl 4-[(2-iodo-4-nitrophenyl)amino]piperidine-1-carboxylateAusbeute 64 %

Versuchsvorschrift

The desired compound was prepared according to the procedure of Example D83, step A, using 1-fluoro-2-iodo-4-nitrobenzene and benzyl 4-aminopiperidine-1-carboxylate as the starting materials in 64% yield. LCMS for C19H211N3O4 (M+H)+: m/z=482.0.

Quellen und Nachweise

ORD-Eintrag
ord-56df9b28f56941dbae0db95e2f1cdde6
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08871753B2

Verknüpfte Notizen

Wird geladen…