tert-Butyl 3-ethynylphenylcarbamate → Methyl [7-({3-[(tert-butoxycarbonyl)amino]phenyl}ethynyl)-5-nitro-2-oxo-1,3-benzoxazol-3(2H)-yl]acetate

HRID 542030

Reaktionsgleichung

Reaktionsgleichung von HRID 542030
I[C:2]1[C:10]2[O:9][C:8](=[O:11])[N:7]([CH2:12][C:13]([O:15][CH3:16])=[O:14])[C:6]=2[CH:5]=[C:4]([N+:17]([O-:19])=[O:18])[CH:3]=1.[C:20]([C:22]1[CH:23]=[C:24]([NH:28][C:29](=[O:35])[O:30][C:31]([CH3:34])([CH3:33])[CH3:32])[CH:25]=[CH:26][CH:27]=1)#[CH:21]>>[C:31]([O:30][C:29]([NH:28][C:24]1[CH:23]=[C:22]([C:20]#[C:21][C:2]2[C:10]3[O:9][C:8](=[O:11])[N:7]([CH2:12][C:13]([O:15][CH3:16])=[O:14])[C:6]=3[CH:5]=[C:4]([N+:17]([O-:19])=[O:18])[CH:3]=2)[CH:27]=[CH:26][CH:25]=1)=[O:35])([CH3:34])([CH3:33])[CH3:32]

Komponenten

3

Edukt 2

HCID 11275982tert-Butyl 3-ethynylphenylcarbamateHCID 57962495Methyl (7-iodo-5-nitro-2-oxo-1,3-benzoxazol-3(2H)-yl)acetate

Produkt 1

HCID 57961919Methyl [7-({3-[(tert-butoxycarbonyl)amino]phenyl}ethynyl)-5-nitro-2-oxo-1,3-benzoxazol-3(2H)-yl]acetate

Versuchsvorschrift

The desired compound was prepared according to the procedure of Example B5, step C, using methyl (7-iodo-5-nitro-2-oxo-1,3-benzoxazol-3(2H)-yl)acetate and tert-butyl (3-ethynylphenyl)carbamate as the starting materials in quantitative yield. LCMS for C23H21N3O8Na (M+Na)+: m/z=490.0.

Quellen und Nachweise

ORD-Eintrag
ord-55ecf3e132b74632a4eb979f444b4758
Quelldatensatz
uspto-grants-2014_10
Patentnummer
US08871753B2

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