Indole-3-Acetic Acid → trans-N-methyl-N-[2-(1-pyrrolidinyl) cyclohexyl]-1H-indole-3-acetamide

Beteiligte Stoffe

Reaktionsschritte

1H-Indole 3-acetic acid (1.05 g, Aldrich) and trans-N-methyl-2-(1-pyrrolidinyl)cyclohexanamine were dissolved in tetrahydrofuran (30 ml) and cyclohexyl carbodiimide (1.24 g) added. The resultant solution was stirred at room temperature overnight, during which time a white precipitate appeared. The solution was filtered and evaporated to an oil, which was chromatographed on silica. Elution with ether gave the product as a white solid (1.3 g), mp 175°-178° C.

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