N-[(6-Methoxypyridin-2-yl)methyl]acetamide → (6-Methoxypyridin-2-yl)methanamine

HRID 542262Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 542262
C([NH:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[N:7]=1)(=O)C.Cl.NCC1C=CC=C(OC)N=1.Cl.NCC1NC(=O)C=CC=1>Cl>[NH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[N:7]=1

Komponenten

5

Edukt 3

HCID 13882972N-[(6-Methoxypyridin-2-yl)methyl]acetamideHCID 13882974(6-Methoxypyridin-2-yl)methanamine hydrochlorideHCID 212435226-(Aminomethyl)pyridin-2(1H)-one hydrochloride

Produkt 1

HCID 13882973(6-Methoxypyridin-2-yl)methanamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

The crude product, 2-acetamidomethyl-6-methoxypyridine from Example 1, was combined with 10 ml of 6N hydrochloric acid, and the resulting mixture was heated at its reflux temperature for about 16 hours. The mixture was evaporated to provide a tan solid residue. The product was determined by infrared and nuclear magnetic resonance spectral analyses to be a mixture of 2-aminomethyl-6-methoxypyridine hydrochloride and 6-aminomethyl-2(1H)-pyridone hydrochloride.

Aufarbeitung

  1. temperaturethe resulting mixture was heated at its
  2. temperaturereflux temperature for about 16 hours
  3. customThe mixture was evaporated
  4. customto provide a tan solid residue

Quellen und Nachweise

ORD-Eintrag
ord-662e8a4a14424aeb82e9c2522529e6aa
Quelldatensatz
uspto-grants-1987_04
Patentnummer
US04656285

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