2-Bromo-2-phenylacetaldehyde → p-Nitroacetophenone

HRID 542278Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 542278
BrC[C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]([C:14]1C=CC([N+]([O-])=O)=CC=1CBr)=[O:13].BrC(C1C=CC=CC=1)C=O>>[N+:9]([C:7]1[CH:6]=[CH:5][C:4]([C:12](=[O:13])[CH3:14])=[CH:3][CH:8]=1)([O-:11])=[O:10]

Komponenten

3

Edukt 2

HCID 108889012-Bromo-2-phenylacetaldehydeHCID 86741403Bromomethyl-p-nitro-phenyl-ketone

Produkt 1

HCID 7487p-NitroacetophenoneAusbeute 98 %

Versuchsvorschrift

One proceeds according to Example 14 but bromomethyl-p-nitro-phenyl-ketone is used as starting material in the place of α-bromo-α-phenyl-acetaldehyde. The reaction mixture is not worked up by the extraction method according to Example 14 but by precipitating the product with 50 ml of water, filtering off the same and washing it three times with 20 ml of water each. Thus 16.1 g of the desired compound are obtained, yield 98%.

Aufarbeitung

  1. extractionThe reaction mixture is not worked up by the extraction method
  2. customby precipitating the product with 50 ml of water
  3. filtrationfiltering off the same and
  4. washwashing it three times with 20 ml of water each

Quellen und Nachweise

ORD-Eintrag
ord-da7cefb13510455987f10dbb2632f5d7
Quelldatensatz
uspto-grants-1987_04
Patentnummer
US04656290

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