Hydrogen Bromide → HCID 21242952, Verbindung

HRID 542743Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 542743
COC1C2CCNCCC=2C=CC=1.C([N:17]1[CH2:23][CH2:22][C:21]2[C:24]([Br:34])=[CH:25][C:26]([S:30]([CH3:33])(=[O:32])=[O:31])=[C:27]([O:28]C)[C:20]=2[CH2:19][CH2:18]1)(=O)C.Cl.COC1C2CCNCCC=2C=CC=1S(C)(=O)=O.Br>>[BrH:34].[OH:28][C:27]1[C:20]2[CH2:19][CH2:18][NH:17][CH2:23][CH2:22][C:21]=2[CH:24]=[CH:25][C:26]=1[S:30]([CH3:33])(=[O:32])=[O:31]

Komponenten

5

Edukt 4

HCID 260Hydrogen BromideHCID 138533586-Methoxy-2,3,4,5-tetrahydro-1H-3-benzazepineHCID 21242920HCID 21242920, VerbindungHCID 21242924HCID 21242924, Verbindung

Produkt 1

HCID 21242952HCID 21242952, Verbindung

Versuchsvorschrift

Following the procedure of Examples 1 and 8, 6-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine is converted via 3-acetyl-6-methoxy-7-methylsulfonyl-9-bromo-2,3,4,5-tetrahydro-1H-3-benzazepine to 6-methoxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride which is treated with hydrobromic acid to give 6-hydroxy-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide.

Quellen und Nachweise

ORD-Eintrag
ord-d5ec705c38b745d59f26a82f6d6014e5
Quelldatensatz
uspto-grants-1987_04
Patentnummer
US04659706

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