2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- → HCID 13826855, Verbindung

HRID 542776Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 542776
[Br:1][C:2]1[CH:13]=[CH:12][C:5]2[S:6][CH:7]=[C:8]([CH:9](Br)Br)[C:4]=2[CH:3]=1.[NH2:14]/[C:15](/[CH3:22])=[CH:16]\[C:17]([O:19][CH2:20][CH3:21])=[O:18]>C(O)C>[Br:1][C:2]1[CH:13]=[CH:12][C:5]2[S:6][CH:7]=[C:8]([CH:9]3[C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:15]([CH3:22])[NH:14][C:15]([CH3:22])=[C:16]3[C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:4]=2[CH:3]=1

Komponenten

4

Edukt 2

HCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-HCID 202072365-Bromo-3-(dibromomethyl)-1-benzothiophene

Produkt 1

HCID 13826855HCID 13826855, VerbindungAusbeute 28,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2.35 g of 5-bromo-3-(dibromomethyl)benzo[b]thiophene and 1.6 g of ethyl 3-aminocrotonate in 4 ml of ethanol was heated to reflux for 14 hours. The mixture was evaporated in vacuo and the residue was purified by chromatography over silica gel to provide 0.8 g of the desired title product, m.p. 68°-70° C.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureto reflux for 14 hours
  3. customThe mixture was evaporated in vacuo
  4. customthe residue was purified by chromatography over silica gel

Quellen und Nachweise

ORD-Eintrag
ord-4ea5379d476648cf9fe3e8e432ad3933
Quelldatensatz
uspto-grants-1987_04
Patentnummer
US04659717

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