Norpyridostigmine → HCID 20205836, Verbindung

HRID 543158

Reaktionsgleichung

Reaktionsgleichung von HRID 543158
[CH3:1][N:2]([CH3:12])[C:3]([O:5][C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1)=[O:4].[Cl:13][CH2:14][O:15][C:16](=[O:22])[CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>>[Cl-:13].[CH3:1][N:2]([CH3:12])[C:3]([O:5][C:6]1[CH:7]=[N+:8]([CH2:14][O:15][C:16](=[O:22])[CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH:9]=[CH:10][CH:11]=1)=[O:4]

Komponenten

3

Edukt 2

HCID 98821NorpyridostigmineHCID 525229Chloromethyl hexanoate

Produkt 1

HCID 20205836HCID 20205836, VerbindungAusbeute 80,2 %

Versuchsvorschrift

3-Dimethylcarbamoyloxypyridine (1.66 g) and chloromethylhexanoate (2.0 g) were heated to 90° C. with stirring for 3 hours. The reaction mixture was treated in a similar manner as described in Example 1 to give 2.65 g of 3-(dimethylcarbamoyloxy)-1-(hexanoyloxymethyl)-pyridinium chloride as colorless powdery crystals. It was impossible to precisely measure the melting point because of high hygroscopicity. The structure was determined by N.M.R.

Aufarbeitung

  1. additionThe reaction mixture was treated in a similar manner

Quellen und Nachweise

ORD-Eintrag
ord-390da6494e7b419eac2dc5ef8c661421
Quelldatensatz
uspto-grants-1987_04
Patentnummer
US04661502

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