5-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine → 5-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine.hydrochloride

HRID 5439

Reaktionsgleichung

Reaktionsgleichung von HRID 5439
[CH3:1][S:2]([NH:5][CH2:6][CH2:7][S:8][C:9]1[N:14]2[CH:15]=[CH:16][N:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1)(=[O:4])=[O:3].[ClH:18].CO>CO>[ClH:18].[CH3:1][S:2]([NH:5][CH2:6][CH2:7][S:8][C:9]1[N:14]2[CH:15]=[CH:16][N:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1)(=[O:4])=[O:3]

Komponenten

4

Edukt 2

HCID 152293635-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridineHCID 21893726Hydrochloride methanol

Produkt 1

HCID 200866555-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine.hydrochlorideAusbeute 89,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of 5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine (543 g, 2 mmoles) in methanol (20 ml) was treated with hydrogen chloride-methanol. After the solvent was distilled off, the residue was crystallized from chloroform ether. Then, the crystals thus obtained were washed with ether and dried to obtain 550 mg of the desired product (89.3%, colorless crystals).

Aufarbeitung

  1. distillationAfter the solvent was distilled off
  2. customthe residue was crystallized from chloroform ether
  3. customThen, the crystals thus obtained
  4. washwere washed with ether
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-90e3544a7e8d48009be88fd306d4e8e7
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05244908

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