Thionyl Chloride → Quinoline-3-carbonyl Chloride

HRID 544350

Reaktionsgleichung

Reaktionsgleichung von HRID 544350
S(Cl)([Cl:3])=O.[N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[C:7]([C:15]([OH:17])=O)[CH:6]=1>>[N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[C:7]([C:15]([Cl:3])=[O:17])[CH:6]=1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 80971Quinoline-3-carboxylic acid

Produkt 1

HCID 11030631Quinoline-3-carbonyl Chloride

Versuchsvorschrift

A 300 ml eggplant-shaped flask was equipped with a Dimroth condenser, a calcium chloride tube and a dropping funnel, and in the flask, 0.6 mol of thionyl chloride was slowly dropped to 0.1 mol of 3-quinolylcarboxylic acid with stirring at room temperature. After completion of the dropping, the resulting mixture was stirred continuously for about 1 hour on an oil bath at an oil bath temperature of 65° C. Thereafter, the excess thionyl chloride was removed under a reduced pressure to obtain 3-quinolylcarboxylic acid chloride.

Aufarbeitung

  1. customA 300 ml eggplant-shaped flask was equipped with a Dimroth condenser, a calcium chloride tube and a dropping funnel
  2. stirringAfter completion of the dropping, the resulting mixture was stirred continuously for about 1 hour on an oil bath at an oil bath temperature of 65° C
  3. customThereafter, the excess thionyl chloride was removed under a reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-174559f5148f4569b93cf67afeb710e1
Quelldatensatz
uspto-grants-1984_05
Patentnummer
US04449516

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