Triethylamine → 3-Cyano-methyl-2-methyl-8-(2-phenylethyl)imidazo[1,2-a]pyridine
Reaktionsgleichung
[NH2:1][C:2]1[C:7]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.Cl[CH:17]([C:21](=O)C)[CH2:18][C:19]#[N:20].[CH2:24](N(CC)CC)C>C(O)C>[C:19]([C:18]1[N:3]2[C:4]([CH3:24])=[CH:5][CH:6]=[C:7]([CH2:8][CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[C:2]2=[N:1][C:17]=1[CH3:21])#[N:20]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
In similar manner, reaction of 2-amino-3-(2-phenylethyl)pyridine (which is prepared by amination of 3-(2-phenyl ethyl)-pyridine with sodium amide in ammonia and N,N-dimethylaniline) with 3-chloro-4-oxo-pentanonitrile in ethanol in the presence of triethylamine gives 3-cyano-methyl-2-methyl-8-(2-phenylethyl)imidazo[1,2-a]pyridine.