Phosphorus oxychloride → 3-Chloromethyl-8-(2-fluorobenzyloxy)-2-methylimidazo[1,2-a]pyridine

HRID 544458Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 544458
[F:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[CH2:4][O:5][C:6]1[C:7]2[N:8]([C:12]([CH2:16]O)=[C:13]([CH3:15])[N:14]=2)[CH:9]=[CH:10][CH:11]=1.P(Cl)(Cl)([Cl:24])=O>>[Cl:24][CH2:16][C:12]1[N:8]2[CH:9]=[CH:10][CH:11]=[C:6]([O:5][CH2:4][C:3]3[CH:18]=[CH:19][CH:20]=[CH:21][C:2]=3[F:1])[C:7]2=[N:14][C:13]=1[CH3:15]

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 20458963HCID 20458963, Verbindung

Produkt 1

HCID 204589533-Chloromethyl-8-(2-fluorobenzyloxy)-2-methylimidazo[1,2-a]pyridine

Versuchsvorschrift

A mixture of 8-(2-fluorobenzyloxy)3-hydroxymethyl-2-methyl-imidazo[1,2-a]pyridine from Example 5 (1 g) and phosphorylchloride (15 ml) was heated under reflux for1 hr. Excess phosphorylchloride was distilled off in vacuo, the residue dissolved in hot ethanolic HCL and the mixture filtered to give the title compound as the hydrochloride salt.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for1 hr
  3. distillationExcess phosphorylchloride was distilled off in vacuo
  4. dissolutionthe residue dissolved in hot ethanolic HCL
  5. filtrationthe mixture filtered

Quellen und Nachweise

ORD-Eintrag
ord-897ce9cb6cf94f23b5992075724e1d19
Quelldatensatz
uspto-grants-1984_05
Patentnummer
US04450164

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