Isopropanol → Isopropyl 4-[7-(3-methylisoxazol-5-yl)heptoxy]benzoate
Reaktionsgleichung
[C:1]([C:4]1[CH:23]=[CH:22][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]2[O:20][N:19]=[C:18]([CH3:21])[CH:17]=2)=[CH:6][CH:5]=1)([OH:3])=[O:2].[CH:24](O)([CH3:26])[CH3:25]>>[CH:24]([O:2][C:1]([C:4]1[CH:5]=[CH:6][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]2[O:20][N:19]=[C:18]([CH3:21])[CH:17]=2)=[CH:22][CH:23]=1)=[O:3])([CH3:26])[CH3:25]Komponenten
3
Versuchsvorschrift
[I; R is CH3, n is 7, X is O, Ar is 4--(CH3)2CHOOCC6H4 ], m.p. 45°-46° C., from 5-[7-(4-carboxyphenoxy)heptyl]-3-methylisoxazole (Example 16) and isopropyl alcohol; MIC vs. rhinovirus Type 2 in vitro=0.23 μg/ml.
Quellen und Nachweise
- ORD-Eintrag
- ord-5ef8e093372941e39c70ce81c084161f
- Quelldatensatz
- uspto-grants-1984_05
- Patentnummer
- US04451476
Notizen zur Reaktion
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