Diethyl Malonate → 3-(4-Carboxybutyl)-5-methylisoxazole

Reaktionsgleichung

[CH3:1][C:2]1[O:6][N:5]=[C:4]([CH2:7][CH2:8][CH2:9]Br)[CH:3]=1.C(OCC)(=O)[CH2:12][C:13]([O:15]CC)=[O:14]>>[C:13]([CH2:12][CH2:9][CH2:8][CH2:7][C:4]1[CH:3]=[C:2]([CH3:1])[O:6][N:5]=1)([OH:15])=[O:14]

Komponenten

Edukt 2

HCID 7761Diethyl Malonate

HCID 133169753-(3-Bromopropyl)-5-methyl-1,2-oxazole

Produkt 1

HCID 133169763-(4-Carboxybutyl)-5-methylisoxazoleAusbeute 56 %

Versuchsvorschrift

3-(4-Carboxybutyl)-5-methylisoxazole was prepared from 5-methyl-3-(3-bromopropyl)isoxazole and diethyl malonate according to the procedure of part (c) above, and was obtained in 56% yield as a colorless solid, m.p. 58°-60° C. when recrystallized from carbon tetrachloride.

Aufarbeitung

customwas obtained in 56% yield as a colorless solid, m.p. 58°-60° C. when
customrecrystallized from carbon tetrachloride

Quellen und Nachweise

ORD-Eintrag: ord-92b78f01729341b7b41f982eda257853
Quelldatensatz: uspto-grants-1984_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04451476

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