1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[3-[4-[(methylamino) methyl]phenyl]-1-pyrrolidinyl]-4-oxo-3-quinolinecarboxylic acid

Beteiligte Stoffe

Reaktionsschritte

Starting from 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (0.80 g, 3.0 mmol) and N-methyl-4-(3-pyrrolidinyl)benzene-methanamine, a procedure analogous to that given in Example 1 provided the title compound (1.11 g, 85%) as an off-white solid, mp 235°-237° C.

Herkunft & Nachweise