Reaktionsgleichung
[Cl:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][N:6]2[C@@H:12]1[O:29][C@H:28]([CH2:30][O:31]C(=O)C)[C@@H:23]([O:24]C(=O)C)[C@H:18]([O:19]C(=O)C)[C@H:13]1[O:14]C(=O)C.[CH2:35]([O:37][C:38]1[CH:46]=[CH:45][C:41]([C:42](Cl)=O)=[CH:40][CH:39]=1)[CH3:36]>>[Cl:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([CH2:42][C:41]1[CH:45]=[CH:46][C:38]([O:37][CH2:35][CH3:36])=[CH:39][CH:40]=1)=[CH:5][N:6]2[C@@H:12]1[O:29][C@H:28]([CH2:30][OH:31])[C@@H:23]([OH:24])[C@H:18]([OH:19])[C@H:13]1[OH:14]Komponenten
3
Versuchsvorschrift
4-Chloro-5-fluoro-1-(2,3,4,6-tetra-O-acetyl-β-D-gluco-pyranosyl)indole obtained in Example 34-(3) and 4-ethoxybenzoyl chloride were treated in a manner similar to Example 27 to give the titled compound as a colorless powder. APCI-Mass m/Z 483/485 (M+NH4). 1H-NMR (DMSO-d6) δ 1.30 (t, J=6.9 Hz, 3H), 3.15-3.50 (m, 4H), 3.64 (m, 2H), 3.96 (q, J=6.9 Hz, 2H), 4.18 (s, 2H), 4.54 (t, J=5.4 Hz, 1H), 5.11 (t, J=5.3 Hz, 1H), 5.17 (d, J=5.0 Hz, 1H), 5.23 (d, J=5.8 Hz, 1H), 5.39 (d, J=9.1 Hz, 1H), 6.82 (d, J=8.5 Hz, 2H), 7.12 (d, J=8.5 Hz, 2H), 7.16 (t, J=9.4 Hz, 1H), 7.30 (s, 1H), 7.56 (dd, J=8.9, 3.9 Hz, 1H).
Quellen und Nachweise
- ORD-Eintrag
- ord-585b208d3a534cb7932a7acc67f93615
- Quelldatensatz
- uspto-grants-2011_05
- Patentnummer
- US07935674B2
Verknüpfte Notizen
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