Hydrochloric Acid → Methyl 2-amino-5-methoxybenzoate

HRID 544976

Reaktionsgleichung

Reaktionsgleichung von HRID 544976
Cl.[NH2:2][C:3]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].[CH3:14]O>>[NH2:2][C:3]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][C:4]=1[C:5]([O:7][CH3:14])=[O:6]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 2779305-Methoxyanthranilic acid

Produkt 1

HCID 13052275Methyl 2-amino-5-methoxybenzoate

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

Hydrogen chloride gas was bubbled through a solution of 2-amino-5-methoxybenzoic acid (5.0 g, 30 mmol) in MeOH (200 mL) for 30 minutes. The solution was heated at 60° C. overnight. The reaction was cooled and the solvent removed in vacuo. The residue was dissolved in water, basified with 5M NaOH and extracted twice with ether. The ether extracts were washed with 5M NaOH and water, dried (MgSO4), filtered and concentrated in vacuo to give i-e (4.25 g, 78%): MS m/z=182 (M+H).

Aufarbeitung

  1. temperatureThe reaction was cooled
  2. customthe solvent removed in vacuo
  3. dissolutionThe residue was dissolved in water
  4. extractionextracted twice with ether
  5. washThe ether extracts were washed with 5M NaOH and water
  6. dry with materialdried (MgSO4)
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo
  9. customto give i-e (4.25 g, 78%)

Quellen und Nachweise

ORD-Eintrag
ord-7fc8fb3b35f1478b8069aee2cc738136
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07935694B2

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