4-Dimethylaminomethylene-8-methyl-3,4-dihydro-1H-benzo[b]azepine-2,5-dione → 2-(3,4-Dimethoxy-phenylamino)-9-methyl-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one
Reaktionsgleichung
CN([CH:4]=[C:5]1[CH2:11][C:10](=[O:12])[NH:9][C:8]2[CH:13]=[C:14]([CH3:17])[CH:15]=[CH:16][C:7]=2[C:6]1=O)C.[CH3:19][O:20][C:21]1[CH:22]=[C:23]([NH:29][C:30]([NH2:32])=[NH:31])[CH:24]=[CH:25][C:26]=1[O:27][CH3:28]>>[CH3:19][O:20][C:21]1[CH:22]=[C:23]([NH:29][C:30]2[N:32]=[CH:4][C:5]3[CH2:11][C:10](=[O:12])[NH:9][C:8]4[CH:13]=[C:14]([CH3:17])[CH:15]=[CH:16][C:7]=4[C:6]=3[N:31]=2)[CH:24]=[CH:25][C:26]=1[O:27][CH3:28]Komponenten
3
Versuchsvorschrift
In a manner similar to method I, 4-((dimethylamino)methylene)-8-methyl-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-g) and 1-(3,4-dimethoxyphenyl)guanidine were converted to I-42 (57%): HRMS Calcd. for C21H20N4O3: 377.1613, Found 377.1613.
Quellen und Nachweise
- ORD-Eintrag
- ord-001d7ccc985b4823a1478a90d193f2aa
- Quelldatensatz
- uspto-grants-2011_05