Nitric Acid → HCID 178526837, Verbindung

HRID 545070Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 545070
[F:1][C:2]([F:11])([F:10])[C:3]1[C:4]([OH:9])=[N:5][CH:6]=[CH:7][CH:8]=1.[N+:12]([O-])([OH:14])=[O:13]>S(=O)(=O)(O)O>[N+:12]([C:7]1[CH:8]=[C:3]([C:2]([F:1])([F:10])[F:11])[C:4]([OH:9])=[N:5][CH:6]=1)([O-:14])=[O:13]

Komponenten

4

Edukt 2

HCID 944Nitric AcidHCID 36784112(1H)-Pyridinone, 3-(trifluoromethyl)-

Produkt 1

HCID 178526837HCID 178526837, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

To 3-trifluoromethyl-pyridin-2-ol (1.63 g, 10 mmol) in concentrated sulfuric acid at 0° C., add dropwise fuming nitric acid (2 mL). Stir the mixture at room temperature for 3 hours and pour onto ice. Collect the precipitate by filtration, air-dry and finally dry in a vacuum oven overnight to give the title compound as a white solid.

Aufarbeitung

  1. additionpour onto ice
  2. customCollect the precipitate
  3. filtrationby filtration
  4. customair-dry
  5. customfinally dry in a vacuum oven overnight

Quellen und Nachweise

ORD-Eintrag
ord-42451f0e310d4e8eaf391acfbea031e5
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07935702B2

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