Phenyltrimethylammonium bromide dibromide → 2-Bromo-1-(5-bromo-3-(trifluoromethyl)pyridin-2-yl)ethanone

HRID 545090Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 545090
[Br:1][C:2]1[CH:3]=[C:4]([C:11]([F:14])([F:13])[F:12])[C:5]([C:8](=[O:10])[CH3:9])=[N:6][CH:7]=1.[Br-:15].[Br-].[Br-].C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1.C1([N+](C)(C)C)C=CC=CC=1>C1COCC1>[Br:15][CH2:9][C:8]([C:5]1[C:4]([C:11]([F:14])([F:12])[F:13])=[CH:3][C:2]([Br:1])=[CH:7][N:6]=1)=[O:10]

Komponenten

4

Edukt 2

HCID 17977687Phenyltrimethylammonium bromide dibromideHCID 586455621-(5-Bromo-3-(trifluoromethyl)pyridin-2-yl)ethanone

Produkt 1

HCID 866051072-Bromo-1-(5-bromo-3-(trifluoromethyl)pyridin-2-yl)ethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Dissolve 1-(5-bromo-3-(trifluoromethyl)pyridin-2-yl)ethanone (0.7 g, 0.0026 mol) in anhydrous THF at room temperature under N2 atmosphere. Add phenyltrimethyl-ammonium tribromide (1.47 g, 0.0039 moles, 1.5 eq.) to the reaction mixture and reflux overnight. Cool the reaction mixture to room temperature, filter the insoluble solid and concentrate the filtrate under vacuum. Purify by column chromatography to afford the title compound as a yellow oil.

Aufarbeitung

  1. filtrationfilter the insoluble solid
  2. concentrationconcentrate the filtrate under vacuum
  3. customPurify by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-663cd03b059e4557847927ba69c5b95b
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07935702B2

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