Sodium Bicarbonate → 6-(8-Chloropyrido[2,3-b]pyrazin-3-yl)-5-(trifluoromethyl)nicotinamide

HRID 545094Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 545094
O[CH:2](O)[C:3]([C:5]1[C:13]([C:14]([F:17])([F:16])[F:15])=[CH:12][C:8]([C:9]([NH2:11])=[O:10])=[CH:7][N:6]=1)=O.[Cl:19][C:20]1[CH:25]=[CH:24][N:23]=[C:22]([NH2:26])[C:21]=1[NH2:27].C([O-])(O)=O.[Na+]>CCO>[Cl:19][C:20]1[C:21]2[C:22](=[N:26][C:3]([C:5]3[C:13]([C:14]([F:17])([F:16])[F:15])=[CH:12][C:8]([C:9]([NH2:11])=[O:10])=[CH:7][N:6]=3)=[CH:2][N:27]=2)[N:23]=[CH:24][CH:25]=1

Komponenten

5

Edukt 3

HCID 516892Sodium BicarbonateHCID 224180044-Chloropyridine-2,3-diamineHCID 671896796-(2,2-Dihydroxyacetyl)-5-(trifluoromethyl)nicotinamide

Produkt 1

HCID 671914016-(8-Chloropyrido[2,3-b]pyrazin-3-yl)-5-(trifluoromethyl)nicotinamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Dissolve 6-(2,2-dihydroxyacetyl)-5-(trifluoromethyl)nicotinamide (8.0 g) in 100.0 mL of EtOH and then add 4-chloro-2,3-diaminopyridine (800 mg) followed by addition of NaHCO3 (3.6 g). Stir the reaction at room temperature for 18 hours under N2 atmosphere. Concentrate the reaction mixture under vacuum, and purify by column chromatography to afford the title product as a yellow solid.

Aufarbeitung

  1. customthe reaction at room temperature for 18 hours under N2 atmosphere
  2. concentrationConcentrate the reaction mixture under vacuum
  3. custompurify by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-5cc52d70bbfa4d979ed3c1009b47bef5
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07935702B2

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