Thionyl Chloride → 1-chloro-(5-chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane

HRID 54514

Reaktionsgleichung

Reaktionsgleichung von HRID 54514
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8](O)[CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)=[N:6][CH:7]=1.S(Cl)([Cl:18])=O>C1(C)C=CC=CC=1>[Cl:18][CH:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=1)[CH2:9][N:10]1[CH:14]=[CH:13][N:12]=[CH:11]1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 19959418HCID 19959418, Verbindung

Produkt 1

HCID 199594231-chloro-(5-chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

1 g of 1-(5-chloro-2-pyridyl)-2-(1H-imidazol-1-yl)ethane-1-ol is dissolved in 2 ml of toluene, 6 ml of thionyl chloride are added and the reaction mixture is stirred for 30 minutes at room temperature. The solvent and the thionyl chloride in excess are distilled off, the residue is dissolved in 2N NaOH, extracted with ethyl acetate, dried over Na2SO4 and evaporated to yield the compound as a colourless oil.

Aufarbeitung

  1. distillationThe solvent and the thionyl chloride in excess are distilled off
  2. dissolutionthe residue is dissolved in 2N NaOH
  3. extractionextracted with ethyl acetate
  4. dry with materialdried over Na2SO4
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-3294db1eb1ce4e988dd4e58e736a0c00
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05622982

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